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KMID : 0604520090350030235
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Journal of the Society of Cosmetic Scientists of Korea
2009 Volume.35 No. 3 p.235 ~ p.241
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Antioxidant Activity of Persicaria perfoliata Extracts
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Ahn You-Jin
Kim Sun-Young
Ok Ju-Hyung
Wang Hyun
Park Chang-Hwa
Kim Sung-Ho
Heo Yun-Suk
Jeon Young-Hee
Park Soo-Nam
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Abstract
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In this study, the antioxidative effects, inhibitory effects on tyrosinase, elastase of Persicaria perfoliata extracts were investigated. The deglycosylated fraction of extract (12.38 μg/mL) showed the most prominent free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activity (FSC50). Reactive oxygen species (ROS) scavenging activities (OSC50) of P. perfoliata extracts on ROS generated in Fe3+-EDTA/H2O2 system were investigated using the luminol-dependent chemiluminescence assay. The ethyl acetate fraction of extract (0.35 μg/mL) showed the most prominent ROS scavenging activity. The protective effects of P. perfoliata extract/fractions on the rose-bengal sensitized photohemolysis of human erythrocytes were investigated. The P. perfoliata extracts suppressed photohemolysis in a concentration dependent manner (1 ~ 50 μg/mL) except the deglycosylated fraction of extract. The inhibitory effect of P. perfoliata extracts on tyrosinase was investigated to assess their whitening efficacy.Inhibitory effects (IC50) on tyrosinase were determined with ethyl acetate fraction of P. perfoliata extract (136.00 μg/mL) and deglycosylated fraction of extract (68.10 μg/mL). Finally, their anti-elastase activities were measured to predict the anti-wrinkle efficacy in the human skin. Inhibitory effects (IC50) on elastase were determined with ethyl acetate fraction of P. perfoliata extract (67.20 μg/mL) and deglycosylated fraction of extract (43.50 μg/mL). These results indicate that extract/fractions of P. perfoliata can function as antioxidants in biological systems, particularly skin exposed to UV radiation by scavenging 1O2 and other ROS, and protect cellular membranes against ROS. Extract/fractions of P. perfoliata can be applicable to new functional cosmetics for antioxidant, antiaging.
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KEYWORD
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Persicaria perfoliata, antioxidative activity, antiaging activity, cosmetics, reactive oxygen species
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